Graded bidirectional synaptic plasticity is composed of switch-like unitary events

Publication Year
2005

Type

Journal Article
Abstract

Biological information storage events are often rapid transitions between discrete states. In neural systems, the initiation of bidirectional plasticity by all-or-none events may help confer robustness on memory storage. Here, we report that at CA3-CA1 hippocampal synapses, individual potentiation and depression plasticity events are discrete and heterogeneous in nature. Individual synapses began from extreme high and low strength states. Unitary plasticity events were all-or-none and drove synaptic strength between extremes in

Journal
Proc Natl Acad Sci U S A
Volume
102
Issue
27
Pages
9679-84
Date Published
07/2005
ISSN Number
0027-8424
Alternate Journal
Proc. Natl. Acad. Sci. U.S.A.
PMID
15983385