@article{130526,
  keywords = {Animals, Rats, memory, Time Factors, Hippocampus, Neuronal Plasticity, Electrophysiology, Synapses, Excitatory Postsynaptic Potentials, Likelihood Functions, Rats, Sprague-Dawley, Long-Term Potentiation},
  author = {Daniel O{\textquoteright}Connor and Gayle Wittenberg and Samuel Wang},
  title = {Graded bidirectional synaptic plasticity is composed of switch-like unitary events},
  abstract = {<p>Biological information storage events are often rapid transitions between discrete states. In neural systems, the initiation of bidirectional plasticity by all-or-none events may help confer robustness on memory storage. Here, we report that at CA3-CA1 hippocampal synapses, individual potentiation and depression plasticity events are discrete and heterogeneous in nature. Individual synapses began from extreme high and low strength states. Unitary plasticity events were all-or-none and drove synaptic strength between extremes in</p>
},
  year = {2005},
  journal = {Proc Natl Acad Sci U S A},
  volume = {102},
  pages = {9679-84},
  month = {07/2005},
  issn = {0027-8424},
  doi = {10.1073/pnas.0502332102},
  language = {eng},
}