@article{189106,
  author = {Marlies Oostland and Mikhail Kislin and Yuhang Chen and Tiffany Chen and Sarah Venditto and Ben Deverett and Samuel S.-H. Wang},
  title = {Cerebellar acceleration of learning in an evidence-accumulation task},
  abstract = {<p>Perturbation to the cerebellum can lead to motor dysfunction, cognitive deficits, and behavioral inflexibility. Here we report that a cerebellum-specific transgenic mouse model with disrupted Purkinje cell function shows unexpectedly accelerated learning on a sensory evidence-accumulation task, as well as enhanced sensory reactivity to touch and auditory cues. Computational latent-state analysis of behavior revealed that accelerated learning was associated with enhanced focus on current over past trials. Learning was also accelerated by providing cue-locked optogenetic stimulation of Purkinje cells, but unaffected by continuous optogenetic interference with Purkinje cell activity. Both transgenic and optogenetically-boosted mice showed prolonged electrophysiological activity in Purkinje-cell complex spikes and anterior cingulate cortex. We suggest that cerebellar activity may shape evidence-accumulation learning by enhancing task focus and neocortical processing of current experience.</p>
},
  year = {2022},
  journal = {bioRxiv},
  month = {07/2022},
  doi = {10.1101/2021.12.23.474034},
}