@article{130486,
  keywords = {Animals, Synaptic Transmission, Biological Evolution, Energy Metabolism, Adaptation, Physiological, Brain, Electrophysiology, Reaction Time, Microscopy, Electron, Neocortex, Axons, Myelin Sheath, Neural Conduction, Mammals},
  author = {Samuel Wang and Jennifer Shultz and Mark Burish and Kimberly Harrison and Patrick Hof and Lex Towns and Matthew Wagers and Krysta Wyatt},
  title = {Functional trade-offs in white matter axonal scaling},
  abstract = {<p>The brains of large mammals have lower rates of metabolism than those of small mammals, but the functional consequences of this scaling are not well understood. An attractive target for analysis is axons, whose size, speed and energy consumption are straightforwardly related. Here we show that from shrews to whales, the composition of white matter shifts from compact, slow-conducting, and energetically expensive unmyelinated axons to large, fast-conducting, and energetically inexpensive myelinated axons. The fastest axons have conduction times of 1-5 ms across the neocortex and</p>
},
  year = {2008},
  journal = {J Neurosci},
  volume = {28},
  pages = {4047-56},
  month = {04/2008},
  issn = {1529-2401},
  doi = {10.1523/JNEUROSCI.5559-05.2008},
  language = {eng},
}